KORA (Kappa Opioid Receptor Agonists)

Finally, there is a potential
new path to pain relief.

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Mu vs. Kappa.

KORAs target pain directly at peripheral
kappa-opioid receptors instead of mu-opioid receptors,
offering a promising new path in treating pain.

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Central vs. Peripheral.

KORAs block pain at it source by
selectively activating kappa-opioid receptors located
on peripheral nerve terminals rather than the CNS.

Unlike mu-opioids, peripheral KORAs have a reduced ability
to cross the blood-brain barrier—minimizing abuse liability
and mu opioid-related side effects.

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When mu-opioid related side effects
are a concern in a peri-operative setting.

Treatment of pain with classical mu opioids is associated with multiple side
effects, including sedation, respiratory depression, constipation, nausea, and
euphoria (which may lead to abuse potential).

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When risk of abuse
is a concern in a clinical setting.

Peripherally restricted kappa opioid receptor agonists have shown
a possible lower abuse potential and side effect burden than mu opioid
receptor agonists making them promising targets for treating pain


When prescribing, what would you like to see in a pain product?

    Efficacy with fewer side-effectsLess potential for abuseA treatment option between NSAIDs and opioids